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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2A All Species: 34.55
Human Site: T1758 Identified Species: 76
UniProt: P24928 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P24928 NP_000928.1 1970 217176 T1758 T S P N Y T P T S P S Y S P T
Chimpanzee Pan troglodytes XP_511300 1913 211215 T1625 T S P S Y S P T S P S Y S P T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_858599 1896 209574 T1614 T S P S Y S P T S P S Y S P T
Cat Felis silvestris
Mouse Mus musculus P08775 1970 217158 T1758 T S P N Y T P T S P S Y S P T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL98 1390 155685 N1180 V C V T P R E N S K S S M Y Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_682682 1972 217631 T1629 T S P S Y S P T S P S Y S P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P04052 1887 209150 S1674 P G N A Y S P S S S N Y S P N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P16356 1852 203961 T1622 T S P S Y S P T S P S Y S P T
Sea Urchin Strong. purpuratus XP_001176260 1921 212544 T1642 T S P S Y S P T S P S Y S P T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P18616 1840 204671 T1604 T S P S Y S P T S P S Y S P T
Baker's Yeast Sacchar. cerevisiae P04050 1733 191593 G1517 A Y G G A D Y G E A T S P F G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.7 N.A. 95.9 N.A. 99.9 N.A. N.A. N.A. 26.2 N.A. 94.9 N.A. 71.1 N.A. 67.4 77.6
Protein Similarity: 100 96.8 N.A. 96 N.A. 99.9 N.A. N.A. N.A. 40.8 N.A. 97.8 N.A. 84.1 N.A. 81 87.2
P-Site Identity: 100 86.6 N.A. 86.6 N.A. 100 N.A. N.A. N.A. 13.3 N.A. 86.6 N.A. 40 N.A. 86.6 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. N.A. 13.3 N.A. 100 N.A. 60 N.A. 100 100
Percent
Protein Identity: N.A. N.A. N.A. 57.4 50.1 N.A.
Protein Similarity: N.A. N.A. N.A. 71.9 64.8 N.A.
P-Site Identity: N.A. N.A. N.A. 86.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 100 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 10 10 0 0 0 0 10 0 0 0 0 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 10 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % F
% Gly: 0 10 10 10 0 0 0 10 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 10 19 0 0 0 10 0 0 10 0 0 0 10 % N
% Pro: 10 0 73 0 10 0 82 0 0 73 0 0 10 82 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 73 0 55 0 64 0 10 91 10 82 19 82 0 0 % S
% Thr: 73 0 0 10 0 19 0 73 0 0 10 0 0 0 73 % T
% Val: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 82 0 10 0 0 0 0 82 0 10 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _